What an MLB source said about the Dbacks trade h

first_img What an MLB source said about the D-backs’ trade haul for Greinke Top Stories 0 Comments   Share   Nevada officials reach out to D-backs on potential relocation Cardinals expect improving Murphy to contribute right away D-backs president Derrick Hall: Franchise ‘still focused on Arizona’ You may think you know football, but there’s no way you could have predicted that Arizona Cardinals receiver Larry Fitzgerald would conduct a symphony orchestra before he’d score a touchdown this season.But that has actually happened. Fitzgerald conducted the Phoenix Symphony Orchestra in a rendition of “The Star-Spangled Banner” Thursday night.Enjoy the video below, and thanks to abc15.com.last_img

Got allergies Blame parasites

first_imgWhy are millions of people allergic to peanuts or pollen, but hardly anyone seems to have a reaction to rice or raisins? Because only some of these things carry molecules similar to those found in parasites that send our immune systems into hyperdrive, according to a new study. The advance could help researchers predict what other foods might cause allergies.Allergies begin when a type of antibody known as Immunoglobulin E (IgE) recognizes a so-called allergen—a peanut protein, for example—and binds to it. In some cases, this causes the immune system to overreact, ultimately leading to symptoms ranging from a runny nose to life-threatening anaphylactic shock.Scientists have long argued that this mechanism originally evolved to defend humans and animals against parasites like certain worms. In developed countries, where people’s immune systems are hardly ever confronted by such parasites, the immune system may begin targeting other molecules by mistake, causing allergic reactions. Click to view the privacy policy. Required fields are indicated by an asterisk (*) Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Emailcenter_img Sign up for our daily newsletter Get more great content like this delivered right to you! Country To bolster this hypothesis, a group of scientists led by computational biologist Nicholas Furnham at the London School of Hygiene & Tropical Medicine looked for similarities among 2712 proteins known to cause allergies and more than 70,000 proteins from 31 species of parasites. Using computer programs that compared the protein sequences as well as their 3D structures, the researchers identified a list of 2445 parasite proteins that are very similar to allergenic proteins. For instance, they found a protein in the worm Schistosoma mansoni that closely resembles one in birch pollen that makes people sneeze.To see whether these predictions checked out in the real world, the scientists collected blood from 222 people in Uganda infected with the worm S. mansoni. They found that about one in six of them produced antibodies that recognized the pure worm protein. “We predicted that this protein in [S.] mansoni should be recognized by the immune system, because a fragment of it is similar to this birch protein which causes allergies,” Furnham says. It is “the first example of a plant pollen–like protein in a worm that is targeted by IgE,” the researchers write today in PLOS Computational Biology.“It’s a very nice paper,” says Maria Yazdanbakhsh, a parasitologist at Leiden University Medical Center in the Netherlands. Some examples of allergens resembling worm proteins were already known, she says, but this is the first systematic look. “They present a method that allows you to identify new allergens. That’s a wonderful tool that can be applied to many things.”One future use would be to screen new foods for possible allergens, Furnham says. The results could even help researchers design better therapies for people suffering from allergies, he argues. In immunotherapy (like allergy shots), people are exposed to increasing doses of an allergen to desensitize their immune systems. Knowing what parasite protein the allergen resembles could allow doctors to give that protein to patients instead of the pollen; that would make it easier to dose the allergy shots, as well as make the immunotherapy safer, Furnham says. “But that is a long way down the line,” he cautions.A worm defense gone awry may explain some, but not all, allergies, says immunologist Ruslan Medzhitov of Yale University. He recently argued that some allergies may have an evolutionary purpose, like keeping humans away from environmental toxins. “Here the authors choose examples of allergens that support their view and ignore the ones that don’t,” he says. “This paper doesn’t change my opinion on the matter.”last_img read more